The Center for Biosignatures Discovery Automation at Arizona State University’s Biodesign Institute seeks to fill a Postdoctoral Research Fellow position in single-cell CT imaging research. The project (a component of a funded PSOC, Physical Sciences in Oncology Center at ASU, see http://beyond.asu.edu/Cancer/index.php) focus is on further development of a new method, called cell CT, for 3D imaging of biological cells. Our overarching objective is to better understand relationships and correlations between cellular genome, transcriptome, structure and function. The cell CT produces 3D images of cells from transmitted or emitted optical pseudoprojections. We call the raw data “pseudoprojections” since it is formed by scanning the focal plane through the specimen at each of hundreds of angular orientations. We use filtered backprojection and other methods to recover the 3D object function from the raw data.
We seek an energetic scientist with significant depth and experience in image reconstruction from projections, preferably for micro-CT. Transmission and emission tomography are both utilized in our research. A PhD in engineering, physics, mathematics, computer science, or other appropriate discipline is required. The successful candidate must have the demonstrated ability to conceive and implement (either by coding in a standard computer language or by use of an environment like Matlab or Mathematica) standard and novel image reconstruction algorithms. Hands-on experience with algorithm implementation is an absolute requirement for the position. Experience with various approaches, including filtered backprojection, analytical (iterative), Fourier, and statistical methods is preferred. The ability to conceive innovative methods and implement algorithms for such ancillary tasks as projection alignment and object motion estimation is required.
Previous practical, hands-on experience with laboratory micro-CT or optical microscope systems is preferred, but not required. Background in optics and optical system conception, design and implementation is desirable. A record including peer-reviewed publications is highly desirable. In addition to research and designing experiments, the successful candidate is expected to be involved in proposal writing and student mentoring activities. Excellent writing and communication skills and the ability to function as a member of a multidisciplinary team are essential. Salary and benefits are competitive. The position is renewable annually for a maximum of three years, contingent on satisfactory performance, availability of funding, and the needs of the program.