Open Seminar – Luis Cisneros – Initiation of Micro-Metastases from Low-Fitness Cancer Cells: Rare, Explosive, and Deterministic
Speaker: Luis Cisneros, PhD. works in the ASU Physics Department and the Beyond Center for Fundamental Questions in Science. He is interested in bio-fluid dynamics and collective phenomena of complex systems. He previously worked extensively in the collective behavior of suspensions of interacting motile bacteria, including experimental research, analysis and characterization of real data, development of models and test simulations. He is currently working on problems related to the migration and colonization processes of metastatic cancer cells, theoretical models of tumor proliferation and transition to malignancy, the Warburg effect and electrical properties of cancer cells.
Location: Biodesign Auditorium
Web Cast: View Web Cast Video
Date & Time: September 22nd, 2011 12:00 p.m.
Title: Initiation of Micro-Metastases from Low-Fitness Cancer Cells: Rare, Explosive, and Deterministic
The final stage of the metastatic cascade, colonization of secondary tissue sites, is very hard to address experimentally and is thus poorly understood. Given the long time-scale of most metastatic disease, it is commonly presumed that colonization arises from rare genetically pre-adapted founding cells. We construct a null model to estimate the relative probability of colonization from common non-pre-adapted cancer cells. We find that the dynamics of rare colonization events in this cell population is explosive and essentially deterministic, and thus indistinguishable from colonization dynamics from pre-adapted cells. And we find, in comparing relative likelihoods of pre-adapted and non-pre-adapted cells, that the latter can dominate if early metastatic tumors self-stabilize at a scale of 20-40 cells. We term this speculative tumor stage as a ‘proto-metastasis’, and comment on how these new insights may lead to new therapeutic interventions of metastatic disease. This is work in progress done in collaboration with Timothy Newman at The University of Dundee.
Thank you and if you have questions please contact Amanda Wilber! And don’t forget, coffee will be served!
Amanda Wilber, Center for the Convergence of Physical Science and Cancer Biology
Arizona State University | P.O. Box 871504 | Tempe, AZ 85287
480.965.3860 | Fax: 480.965.6362