Rod McEver – “Force-regulated adhesion of leukocytes to vascular surfaces”
Speaker: Rod McEver, MD, holds a B.A. from Yale University and earned his medical degree at the University of Chicago. He joined OMRF’s scientific staff in 1987 and currently holds the Eli Lilly Chair in Biomedical Research. Previously, McEver was a George Lynn Cross Research Professor at the University of Oklahoma Health Sciences Center, where he remains an adjunct professor of biochemistry and molecular biology.
In 2004, McEver secured more than $4 million in National Institutes of Health grants, making him one of the most highly funded researchers in Oklahoma. “Rod McEver is a tremendous scientist, and I have no doubt he will provide both a steady hand and tremendous vision as he guides our researchers into a new period of growth and discovery,” said OMRF President J. Donald Capra, M.D.
Location: Biodesign Auditorium
Web Cast: View Live Web Cast
Date & Time: November 29th, 2012 12:00 p.m.
Title: Force-regulated adhesion of leukocytes to vascular surfaces
Abstract: During inflammation, flowing leukocytes tether to and roll on activated endothelial cells, then decelerate and arrest before they emigrate into the underlying tissues. Interactions of selectins with glycosylated ligands mediate leukocyte rolling, a prerequisite for integrin-mediated deceleration and arrest. Counterintuitively, rolling requires a minimal flow rate, or shear threshold. As flow drops below this threshold, rolling becomes more rapid and irregular until the cells detach. Shear stress applies force to bonds between selectins and their ligands, which affects their lifetimes. As flow increases from suboptimal levels, force first prolongs bond lifetimes (catch bonds) until they reach a maximal level. Further increases in force shorten bond lifetimes (slip bonds). Catch bonds between selectins and ligands enable flow-enhanced adhesion of leukocytes to vascular surfaces and may prevent inappropriate agglutination of circulating cells. Recent data indicate that the mechanical environment of blood flow influences the functions of other adhesion receptors on leukocytes and platelets during infection or tissue injury. Mechanical forces might also regulate migration of tumor cells in extravascular tissues and metastasis of tumor cells through the blood stream.
Thank you and if you have questions please contact Amanda Wilber! And don’t forget, coffee will be served!
Amanda Wilber, Center for the Convergence of Physical Science and Cancer Biology
Arizona State University | P.O. Box 871504 | Tempe, AZ 85287
480.965.3860 | Fax: 480.965.6362