Speaker: Dr. Sui Huang is a molecular and cell biologist at the Institute for Systems Biology in Seattle. He studies cancer from a complex systems perspective, seeking to understand the phenomenon of multi-cellularity in health and disease because cancer is the price we pay for having evolved a complex multicellular system. The goal is to arrive at a new level of understanding of cancer using the new powerful tools of the epigenetic landscape and by considering cell population dynamics. Using state-of-the art single cell resolution measurement of gene expression patterns coupled with monitoring their phenotypic consequences, the Huang lab examines the generic properties of spontaneous cell state diversification and of regulated cell fate switching in multipotent cells and cancer stem cells. Such experiments unveil the non-genetic (“epigenetic”) aspects of tumor progression hat have been neglected.
Location: Biodesign Auditorium
Web Cast: View Video Online
Date & Time: September 5th, 2013 12:00 p.m.
Title: Cancer attractors and cell population dynamics: The non-genetic, non-Darwinian (Lamarckian) evolution of cancer drug resistance
Abstract:Cancer is a disruption of normal cell development. In the view of the quasi-potential landscape of gene networks, cancer arises because cells are pushed into developmentally inaccessible, evolutionary ancient “side-valleys” – the cancer attractors. I will present experiments supporting this alternative view and apply such non-genetic dynamics to show how Lamarckian (as opposed to Darwinian) dynamics initiates development of cancer drug resistance.
Thank you and if you have questions please contact Christina Cates! And don’t forget, coffee will be served!
Christina Cates, Center for the Convergence of Physical Science and Cancer Biology
Arizona State University | P.O. Box 871504 | Tempe, AZ 85287
480.965.0342 | Fax: 480.965.6362