The story behind the remarkable development of a cancer cactus garden at Arizona State University has just appeared in Leonardo (August 2021). Leonardo is a leading journal that integrates science and the arts. The living-art garden, named for the beautiful quote by Charles Darwin, has naturally mutated, crested cacti and inspires researchers and the public alike to consider new approaches to understanding cancer. Read about the motivation behind the cactus garden and how the care of plants, particularly arable crops, stimulated cancer researchers to develop a new form of treatment to care for people with metastatic disease, which is starting to be used in the clinic!