New study explores cancer prevalence in hundreds of vertebrate species

New study explores cancer prevalence in hundreds of vertebrate species

Featured news, News, Research Papers

In a major study of almost 300 vertebrate species published in the journal, Cancer Discovery, ACE researchers examined over 16,000 necropsy records to look for the incidence of cancer across species.  Among the findings of this ten year study, the team discovered that...
Resistance Management for Cancer: Lessons from Farmers

Resistance Management for Cancer: Lessons from Farmers

Featured news, Research Papers

Preventing cancer cells becoming resistant to treatment drugs is one of the trickiest problems facing oncologists, yet farmers have worked out ways to manage an analogous problem – controlling the development of resistance to chemicals by the pests in their...

Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer

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The biggest obstacle to curing cancer is the fact that cancers often harbor resistant cells that are unaffected by cancer drugs. A team that includes several ACE researchers tested a new strategy, called adaptive therapy, for maintaining control over resistant cells...
Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

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Cancer in elephants is very rare, and in order to understand just how they are protected from the disease despite their size and long lifespan, a team including ACE researchers studied their TP-53 genes. Their results appeared in Nature, Cell Death Discovery in...

Is chimerism associated with cancer across the tree of life?

News, Research Papers

In this intriguing paper published in PLOS ONE in June 2023, ACE researchers and their colleagues studied the association between chimerism and cancer across the tree of life.  A chimera is an organism has that has cells from two or more genetically distinct sources. ...
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