Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria
Cancer in elephants is very rare, and in order to understand just how they are protected from the disease despite their size and long lifespan, a team including ACE researchers studied their TP-53 genes. Their results appeared in Nature, Cell Death Discovery in...Is chimerism associated with cancer across the tree of life?
In this intriguing paper published in PLOS ONE in June 2023, ACE researchers and their colleagues studied the association between chimerism and cancer across the tree of life. A chimera is an organism has that has cells from two or more genetically distinct sources. ...The evolutionary theory of cancer: challenges and potential solutions
In this Perspective article in Nature Reviews Cancer, Carlo Maley and his colleague, Lucie Laplane, point out that there is much yet to understand about the many theories and models of cancer evolution in order to discover the best way to treat and prevent the...Cells eating other Cells – found across the tree of life!
In this fascinating study in Scientific Reports, ACE researchers, Stefania Kapsetaki (now at Tufts University), Luis H. Cisneros and Carlo Maley trawled the literature to discover that cell-on-cell cannibalism is a behavior that occurs in both cancer cells and normal...Birds species that lay more eggs get more cancer
Bird species that have small clutches tend to get less cancer than species that have large clutches. That’s the conclusion of an international team of scientists that includes several ACE researchers. The team studied the necropsy records of close to 6000...
