Resistance Management for Cancer: Lessons from Farmers

Featured news, Research Papers

Preventing cancer cells becoming resistant to treatment drugs is one of the trickiest problems facing oncologists, yet farmers have worked out ways to manage an analogous problem – controlling the development of resistance to chemicals by the pests in their...

Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer

Featured news, News, Research Papers

The biggest obstacle to curing cancer is the fact that cancers often harbor resistant cells that are unaffected by cancer drugs. A team that includes several ACE researchers tested a new strategy, called adaptive therapy, for maintaining control over resistant cells...

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

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Cancer in elephants is very rare, and in order to understand just how they are protected from the disease despite their size and long lifespan, a team including ACE researchers studied their TP-53 genes. Their results appeared in Nature, Cell Death Discovery in...

Is chimerism associated with cancer across the tree of life?

News, Research Papers

In this intriguing paper published in PLOS ONE in June 2023, ACE researchers and their colleagues studied the association between chimerism and cancer across the tree of life.  A chimera is an organism has that has cells from two or more genetically distinct sources. ...

The evolutionary theory of cancer: challenges and potential solutions

News, Research Papers

In this Perspective article in Nature Reviews Cancer, Carlo Maley and his colleague, Lucie Laplane, point out that there is much yet to understand about the many theories and models of cancer evolution in order to discover the best way to treat and prevent the...

Cells eating other Cells – found across the tree of life!

News, Research Papers

In this fascinating study in Scientific Reports, ACE researchers, Stefania Kapsetaki (now at Tufts University), Luis H. Cisneros and Carlo Maley trawled the literature to discover that cell-on-cell cannibalism is a behavior that occurs in both cancer cells and normal...